One year following the launch of the All of Us Research Program, what have we learned about how to build an engaged and diverse participant community and its potential for scientific impact? All of Us hosted a Facebook Live session, hosted on the National Institutes of Health (NIH) Facebook page, to address these important questions. Speakers included National Institutes of Health Director Dr. Francis Collins, All of Us Research Program Director Eric Dishman, All of Us Participant Ambassador Ana Pavón, National Heart, Lung, and Blood Institute Director Dr. Gary Gibbons, National Institute on Drug Abuse Director Dr. Nora Volkow, and talks from our colleagues at Verily, Ciitizen, the Hunter-Bellevue School of Nursing, and the University of Illinois at Chicago. Watch the archived event on Facebook Live or via NIH Videocast.